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The Collaborative Network for European Clinical trials for Children-Conect4CHildren (C4C) project, coordinated by Penta Foundation Onlus, aims at improving the sustainabilty and impact of the research on childhood diseases: through an extended European network, it promises it will realise an integrated platform allowing new drugs and therapies to be developed more easily and quickly for the entire pediatric population. The C4C project - started on 1st May 2018 and expected to end on 30th April 2024 - is financed by the IMI 2 European program and supported by the European Union (Horizon 2020) and by the European Federation of Pharmaceutical Industries and Associations. In such context, Arsenàl.IT will take part in the Work Package 4 Scientific Advice, feasibility and innovation supporting its partners in the framework of the Health Technology Assessment (HTA).